The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Non-invasive prostate cancer detection from MRI has the potential to revolutionize patient care by providing early detection of clinically-significant disease (ISUP grade group >= 2), but has thus far shown limited positive predictive value. To address this, we present an MRI-based deep learning method for predicting clinically significant prostate cancer applicable to a patient population with subsequent ground truth biopsy results ranging from benign pathology to ISUP grade group~5. Specifically, we demonstrate that mixed supervision via diverse histopathological ground truth improves classification performance despite the cost of reduced concordance with image-based segmentation. That is, where prior approaches have utilized pathology results as ground truth derived from targeted biopsies and whole-mount prostatectomy to strongly supervise the localization of clinically significant cancer, our approach also utilizes weak supervision signals extracted from nontargeted systematic biopsies with regional localization to improve overall performance. Our key innovation is performing regression by distribution rather than simply by value, enabling use of additional pathology findings traditionally ignored by deep learning strategies. We evaluated our model on a dataset of 973 (testing n=160) multi-parametric prostate MRI exams collected at UCSF from 2015-2018 followed by MRI/ultrasound fusion (targeted) biopsy and systematic (nontargeted) biopsy of the prostate gland, demonstrating that deep networks trained with mixed supervision of histopathology can significantly exceed the performance of the Prostate Imaging-Reporting and Data System (PI-RADS) clinical standard for prostate MRI interpretation.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Named entity recognition models (NER), are widely used for identifying named entities (e.g., individuals, locations, and other information) in text documents. Machine learning based NER models are increasingly being applied in privacy-sensitive applications that need automatic and scalable identification of sensitive information to redact text for data sharing. In this paper, we study the setting when NER models are available as a black-box service for identifying sensitive information in user documents and show that these models are vulnerable to membership inference on their training datasets. With updated pre-trained NER models from spaCy, we demonstrate two distinct membership attacks on these models. Our first attack capitalizes on unintended memorization in the NER's underlying neural network, a phenomenon NNs are known to be vulnerable to. Our second attack leverages a timing side-channel to target NER models that maintain vocabularies constructed from the training data. We show that different functional paths of words within the training dataset in contrast to words not previously seen have measurable differences in execution time. Revealing membership status of training samples has clear privacy implications, e.g., in text redaction, sensitive words or phrases to be found and removed, are at risk of being detected in the training dataset. Our experimental evaluation includes the redaction of both password and health data, presenting both security risks and privacy/regulatory issues. This is exacerbated by results that show memorization with only a single phrase. We achieved 70% AUC in our first attack on a text redaction use-case. We also show overwhelming success in the timing attack with 99.23% AUC. Finally we discuss potential mitigation approaches to realize the safe use of NER models in light of the privacy and security implications of membership inference attacks.

本文报道的研究通过应用计算机视觉技术将普通的垃圾桶转化为更聪明的垃圾箱。在传感器和执行器设备的支持下，垃圾桶可以自动对垃圾进行分类。特别是，垃圾箱上的摄像头拍摄垃圾的照片，然后进行中央处理单元分析，并决定将垃圾桶放入哪个垃圾箱中。我们的垃圾箱系统的准确性达到90％。此外，我们的模型已连接到Internet，以更新垃圾箱状态以进行进一步管理。开发了用于管理垃圾箱的移动应用程序。

预测药物 - 药物相互作用（DDI）是使用药物信息和许多对的已知副作用预测一对药物的副作用（不需要的结果）的问题。该问题可以制定为DDI图中每对节点的预测标签（即副作用），其中节点是药物，边缘是用已知标记的相互作用的药物。本问题的最先进方法是图形神经网络（GNN），其利用图中的邻居信息来学习节点表示。然而，对于DDI而言，由于副作用的性质，有许多具有复杂关系的标签。通常的GNN经常将标签固定为不反映标签关系的单热量矢量，并且可能在困难的难度标签中没有获得最高性能。在本文中，我们将DDI标准为一个超图，其中每个HINFEGE是三重：用于药物的两个节点和标签的一个节点。然后，我们呈现CentsMoothie，一个超图神经网络，它通过新颖的中央平滑制剂完全了解节点和标签的表示。我们经验展示了模拟中的CentsMoothie的性能优势以及真实数据集。

Here, we demonstrate how machine learning enables the prediction of comonomers reactivity ratios based on the molecular structure of monomers. We combined multi-task learning, multi-inputs, and Graph Attention Network to build a model capable of predicting reactivity ratios based on the monomers chemical structures.

As one of the most important psychic stress reactions, micro-expressions (MEs), are spontaneous and transient facial expressions that can reveal the genuine emotions of human beings. Thus, recognizing MEs (MER) automatically is becoming increasingly crucial in the field of affective computing, and provides essential technical support in lie detection, psychological analysis and other areas. However, the lack of abundant ME data seriously restricts the development of cutting-edge data-driven MER models. Despite the recent efforts of several spontaneous ME datasets to alleviate this problem, it is still a tiny amount of work. To solve the problem of ME data hunger, we construct a dynamic spontaneous ME dataset with the largest current ME data scale, called DFME (Dynamic Facial Micro-expressions), which includes 7,526 well-labeled ME videos induced by 671 participants and annotated by more than 20 annotators throughout three years. Afterwards, we adopt four classical spatiotemporal feature learning models on DFME to perform MER experiments to objectively verify the validity of DFME dataset. In addition, we explore different solutions to the class imbalance and key-frame sequence sampling problems in dynamic MER respectively on DFME, so as to provide a valuable reference for future research. The comprehensive experimental results show that our DFME dataset can facilitate the research of automatic MER, and provide a new benchmark for MER. DFME will be published via https://mea-lab-421.github.io.

Face Anti-spoofing (FAS) is essential to secure face recognition systems from various physical attacks. However, recent research generally focuses on short-distance applications (i.e., phone unlocking) while lacking consideration of long-distance scenes (i.e., surveillance security checks). In order to promote relevant research and fill this gap in the community, we collect a large-scale Surveillance High-Fidelity Mask (SuHiFiMask) dataset captured under 40 surveillance scenes, which has 101 subjects from different age groups with 232 3D attacks (high-fidelity masks), 200 2D attacks (posters, portraits, and screens), and 2 adversarial attacks. In this scene, low image resolution and noise interference are new challenges faced in surveillance FAS. Together with the SuHiFiMask dataset, we propose a Contrastive Quality-Invariance Learning (CQIL) network to alleviate the performance degradation caused by image quality from three aspects: (1) An Image Quality Variable module (IQV) is introduced to recover image information associated with discrimination by combining the super-resolution network. (2) Using generated sample pairs to simulate quality variance distributions to help contrastive learning strategies obtain robust feature representation under quality variation. (3) A Separate Quality Network (SQN) is designed to learn discriminative features independent of image quality. Finally, a large number of experiments verify the quality of the SuHiFiMask dataset and the superiority of the proposed CQIL.

Image Virtual try-on aims at replacing the cloth on a personal image with a garment image (in-shop clothes), which has attracted increasing attention from the multimedia and computer vision communities. Prior methods successfully preserve the character of clothing images, however, occlusion remains a pernicious effect for realistic virtual try-on. In this work, we first present a comprehensive analysis of the occlusions and categorize them into two aspects: i) Inherent-Occlusion: the ghost of the former cloth still exists in the try-on image; ii) Acquired-Occlusion: the target cloth warps to the unreasonable body part. Based on the in-depth analysis, we find that the occlusions can be simulated by a novel semantically-guided mixup module, which can generate semantic-specific occluded images that work together with the try-on images to facilitate training a de-occlusion try-on (DOC-VTON) framework. Specifically, DOC-VTON first conducts a sharpened semantic parsing on the try-on person. Aided by semantics guidance and pose prior, various complexities of texture are selectively blending with human parts in a copy-and-paste manner. Then, the Generative Module (GM) is utilized to take charge of synthesizing the final try-on image and learning to de-occlusion jointly. In comparison to the state-of-the-art methods, DOC-VTON achieves better perceptual quality by reducing occlusion effects.